Goals before the break from Leonardo Spinazzola and Amir Rrahmani secured a 2-0 triumph for the visitors at the Stadio Olimpico in a match marred by three dismissals.
Three points propels Conte's side to just one point behind of Italian league pace-setters Milan, who prevailed on Friday. Inter occupy third place but can return to the top with a victory in their evening fixture.
Despite missing several key players, Napoli commanded the game with measured attacks. The opener arrived when Matteo Politano's delivery was drilled home by the wing-back at the back post.
The advantage was extended in the 32nd minute as Rrahmani guided a header from another Politano free-kick into the bottom corner. Napoli went close to a third shortly after when Eljif Elmas saw his effort crash against the woodwork.
The second half brought more injury concern for the away side when a winger limped off. This incident triggered a short altercation, resulting in yellow cards for a Napoli defender and the home side's Tijjani Noslin—who then received a second caution for a foul.
"I must congratulate the lads, playing with such a high standard of quality and physical strength without letting the opposition play is not easy," stated the winning manager. "Our performance was at a very high level of play."
Tempers boiled over again near the end as two opponents were embroiled in a fierce exchange, prompting the coach to intervene. The two players were sent off for their part in the clash.
Over in La Liga, Sevilla endured a 3-0 defeat at home to struggling the Granotas. The visitors established a lead with a fine move before adding two more goals in the second half to complete a convincing win.
Meanwhile, Real Madrid face significant must-win when they welcome Real Betis, after their arch-rivals extended their lead at the top. Later on other game, Atleti make the journey to face La Real.
In France, a historic capital clasico takes place as the newly-promoted side visit powerhouses Paris Saint-Germain. The fixture represents the first top-flight meeting between the two clubs in decades, bringing significant intrigue to the weekend's action.
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